CYP3A5 polymorphism, amlodipine and hypertension
نویسندگان
چکیده
منابع مشابه
Combination of aliskiren and amlodipine in hypertension
Hypertension frequently resists control with monotherapy, requiring two or more antihypertensive agents in combination. Many antihypertensive fixed-dose combinations (FDCs) combine drugs with different, but complementary, mechanisms of action to improve overall efficacy and tolerability. Antihypertensive FDCs may provide significant advantages over high-dose monotherapy, such as improved effica...
متن کاملEffect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro.
Previous investigations of solid organ transplant patients treated with tacrolimus showed that individuals carrying a CYP3A5*1 allele have lower dose-adjusted trough blood concentrations compared with homozygous CYP3A5*3 individuals. The objective of this investigation was to quantify the contribution of CYP3A5 to the hepatic and renal metabolic clearance of tacrolimus. Four primary tacrolimus ...
متن کاملBenazepril plus amlodipine or hydrochlorothiazide for hypertension.
To the Editor: In their report on the Avoiding Cardiovascular Events through Combination Ther apy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial, Jamerson et al. (Dec. 4 is sue)1 challenge current treatment recommenda tions for hypertension. In the study, they report ed that the use of combined therapy with an angiotensinconverting–enzyme (ACE) inhibitor, benazepril, plus...
متن کاملImpact of CYP3A5 Gene Polymorphism on Efficacy of Simvastatin
BACKGROUND One of the promises of human genetics is individualized therapy. Therefore, we evaluated the impact of CYP3A5 gene polymorphism on the effectiveness of simvastatin (a HMG-CoA reductase inhibitor). METHODS Patients (n = 191) with hypercholesterolemia were treated with simvastatin for at least 6 months and were genotyped for the CYP3A5 polymorphism. RESULTS The frequency of CYP3A5 ...
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Calcium channel blockers (CCBs) blunt postural skin vasoconstriction, an autoregulatory mechanism that minimizes gravitational increases in capillary pressure and avoids fluid extravasation when standing. To evaluate the dose-response relation between this pharmacological interference and dependent edema, a frequent side effect of CCBs during antihypertensive treatment, skin blood flow (laser D...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 2013
ISSN: 0950-9240,1476-5527
DOI: 10.1038/jhh.2013.67